Narcolepsy

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Summary of Rationale Behind and Research Studies into L-carnitine as a Treatment for Narcolepsy

Background In this 2013 study published in PLoS One, the researchers Miyagawa et al hypothesized that L-carnitine supplementation might help improve narcolepsy symptoms by increasing β-fatty-acid oxidation. Fatty acids are a major energy source for the human body. For them to be broken down and metabolized via oxidation...

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EMA Recommends Approval of Pitolisant for the Treatment of Narcolepsy

On November 20, 2015, the European Medicine Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) recommended that Bioprojet Pharma's drug pitolisant (Wakix) be approved for the treatment of narcolepsy with or without cataplexy. In making its recommendation, the Committee reviewed data from four studies of pitolisant—two placebo-controlled...

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A Comparison of Sodium Oxybate in the Treatment of Idiopathic Hypersomnia and Narcolepsy Type 1

Background Sodium oxybate (SXB) is a drug sold as Xyrem in the United States by Jazz Pharmaceuticals, in Europe by UCB Pharma, and in Canada by Valeant Pharmaceuticals. It is approved in the United States in adults for the treatment of excessive daytime sleepiness (EDS) and...

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Does Excessive Daytime Sleepiness Affect Children’s Pedestrian Safety?

Background Each year, approximately 30,000 children are unintentionally killed or injured while walking outside (typically within a half mile of their homes). Many factors—including children’s thinking and reasoning abilities, attention spans, reaction times, impulsiveness, and willingness to take risks—likely play a role. Excessive daytime sleepiness (EDS),...

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Antibiotic May Decrease EDS in GABA-Related Hypersomnia

A study of clarithromycin in the treatment of GABA-related hypersomnia indicates that this drug may be effective in some patients with idiopathic hypersomnia (IH), narcolepsy without cataplexy, and subjective hypersomnia. Background The US Food and Drug Administration (FDA) has not approved any drugs for the treatment of IH....

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It’s a Fine Line Between Type 2 Narcolepsy and Idiopathic Hypersomnia… and It’s Getting Even Finer

Researchers have provided more evidence that narcolepsy without cataplexy (Nw/oC ) and idiopathic hypersomnia (IH) without long sleep time (LST) look more alike on testing than do narcolepsy with cataplexy (NwC) and Nw/oC. This research was completed before the publication of the International Classification of Sleep Disorders...

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Dr. David Rye Presents at 2013 Narcolepsy Network

Dr. David Rye's 2013 session at the Narcolepsy Network conference entitled: What's in a Name? Understanding the Origins of the Terminologies for the Family of Hypersomnias. A fascinating examination of semantics and the signs and symptoms of hypersomnia. Recorded by: Diana Kimmel Edited by: Jennifer Beard Uploaded with...

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