Kleine-Levin Syndrome

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How Does GABA Affect Hypersomnia? Part 2 of Our Video Series Explains!

What is GABA? What role does it play in sleep? And is GABA activity increased by something in the cerebrospinal fluid of people with hypersomnia? We are very pleased to present Part 2 of a new two-part series by neuroscientist Amanda Freeman, PhD, of Emory...

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What Is GABA? How Does It Affect Hypersomnia? A New Video Series Explains!

Amanda Freeman, PhD What is GABAA? And how does it affect hypersomnia? We are very pleased to present a two-part video series by neuroscientist Amanda Freeman, PhD, of Emory University, which describes, in layman’s terms, exactly how y-aminobutyric acid, better known as GABA, affects sleep....

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Ask the Doctor: Do Women’s Hormones Affect Their Hypersomnia?

Can menstrual cycles trigger hypersomnia episodes? Can taking hormones tame these symptoms? And does IH affect more women than men? We are delighted to have our Medical Advisory Board member Dr. Isabelle Arnulf, a Professor of Neurology at the Sorbonne University and one of the...

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Ask the Doctor: What Is POTS, and What Does It Have to Do with Hypersomnia?

Although the Hypersomnia Foundation is not currently accepting new submissions for its Ask the Doctor series, we are working to answer previously submitted questions that are of general interest to our hypersomnia community. Today we have Dr. Mitchell Miglis of Stanford, a renowned expert in...

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Act Today and Let Your Voice Be Heard

Very recently, the Hypersomnia Foundation became aware of an opportunity to help shape the future of sleep research. The National Institutes of Health, the primary source of funding for medical research in the United States, has issued a Request for Information, which you can view at: https://grants.nih.gov/grants/guide/notice-files/NOT-HL-16-312.html. The final date to...

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Antibiotic May Decrease EDS in GABA-Related Hypersomnia

A study of clarithromycin in the treatment of GABA-related hypersomnia indicates that this drug may be effective in some patients with idiopathic hypersomnia (IH), narcolepsy without cataplexy, and subjective hypersomnia. Background The US Food and Drug Administration (FDA) has not approved any drugs for the treatment of IH....

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New Findings in a Large Well-defined Group of People with KLS

Background Kleine Levin syndrome (KLS) is a neuropsychiatric disease that affects about 1 in a million people. Symptoms include hypersomnia, confusion, derealization, hypersexuality, megaphagia, altered mood, and hallucinations that occur during recurrent episodes, with normal sleep, thinking, mood, and behavior between episodes. Most people who have KLS...

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Summary of Research into Clarithromycin as a Hypersomnia Treatment

GABA is known to promote sleep and decreased consciousness, and many patients with CNS hypersomnia have been found to have endogenous GABA-A receptor hyper-reactivity.  Flumazenil, a known GABA-A antagonist, has been shown to reduce symptoms in these patients, but its use may be impractical; therefore,...

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Today Show Features Teenager with KLS

This episode of the Today Show, which originally aired on November 20, 2012, offers a glimpse into the sleep-filled life of Nicole Delien, a 17-year-old with Kleine-Levin syndrome, and provides an interview with the physician who diagnosed her disorder, Dr. Michael Rancurello. https://www.today.com/video/real-life-sleeping-beauty-slept-64-days-in-a-row-44548675700 Visit NBCNews.com for breaking...

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