SomnusNooze e-newsletter
News, stories and updates from the world of sleep
SomnusNooze topics: Journal article summaries
How Long Does It Take for Sodium Oxybate to Work?
Background According to the Narcolepsy Network, although it affects more than 200,000 people in the U.S., narcolepsy is estimated to be undiagnosed or untreated in 75% of people with the disorder. This lack of recognition leads to delays in effective... read >
Can Actigraphy Help to Differentiate People with Narcolepsy from People with Idiopathic Hypersomnia?
Why is this study important? Type 1 narcolepsy (T1N) and idiopathic hypersomnia (IH) are both disorders of central hypersomnolence. Even though the International Classification of Sleep Disorders, third edition, includes a finding of 11 hours of sleep... read >
Hypocretin Level as a Biomarker in KLS
Background Kleine-Levin syndrome (KLS) is a rare disorder in which affected people experience episodes at least once per year during which they sleep for at least 11 hours out of every day (but often for days at a time), eat excessively (megaphagia),... read >
Does Modafinil Improve Sleepiness in People With IH Without Long Sleep Time?
Background In Europe, modafinil used to be available as a treatment for the excessive daytime sleepiness (EDS) associated with idiopathic hypersomnia (IH). However, in 2010, the European Medicines Agency (EMA, the equivalent of the Food and Drug... read >
Summary of Research into Clarithromycin as a Hypersomnia Treatment
GABA is known to promote sleep and decreased consciousness, and many patients with CNS hypersomnia have been found to have endogenous GABA-A receptor hyper-reactivity. Flumazenil, a known GABA-A antagonist, has been shown to reduce symptoms in these... read >