Journal Article Summaries

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Can Actigraphy Help to Differentiate People with Narcolepsy from People with Idiopathic Hypersomnia?

Why is this study important? Type 1 narcolepsy (T1N) and idiopathic hypersomnia (IH) are both disorders of central hypersomnolence. Even though the International Classification of Sleep Disorders, third edition, includes a finding of 11 hours of sleep during a 24-hour period (as measured by actigraphy for at least 7...

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Does Modafinil Improve Sleepiness in People with IH without Long Sleep Time?

Background In Europe, modafinil used to be available as a treatment for the excessive daytime sleepiness (EDS) associated with idiopathic hypersomnia (IH). However, in 2010, the European Medicines Agency (EMA, the equivalent of the Food and Drug Administration in the United States) changed the labeling, and...

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Summary of Research into Clarithromycin as a Hypersomnia Treatment

GABA is known to promote sleep and decreased consciousness, and many patients with CNS hypersomnia have been found to have endogenous GABA-A receptor hyper-reactivity.  Flumazenil, a known GABA-A antagonist, has been shown to reduce symptoms in these patients, but its use may be impractical; therefore,...

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