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What Does One SOREMP Mean?

Background The primary feature of the two main central disorders of hypersomnolence—narcolepsy and idiopathic hypersomnia (IH)—is excessive daytime sleepiness, defined in the International Classification of Sleep Disorders, third edition, as “daily episodes of an irrepressible need to sleep or daytime lapses into sleep." Overnight sleep testing (polysomnography) and a...

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Summary of Rationale Behind and Research Studies into L-carnitine as a Treatment for Narcolepsy

Background In this 2013 study published in PLoS One, the researchers Miyagawa et al hypothesized that L-carnitine supplementation might help improve narcolepsy symptoms by increasing β-fatty-acid oxidation. Fatty acids are a major energy source for the human body. For them to be broken down and metabolized via oxidation...

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The First Multi-Site Clinical Trial for IH and Type 2 Narcolepsy in the US Is Underway

ARISE 201 is the first double-blind, placebo-controlled, crossover, multicenter study of a drug (BTD-001) for the treatment of idiopathic hypersomnia (IH) and type 2 narcolepsy (T2N) in adults. More than 20 study sites throughout the United States are currently prescreening or screening people with IH and T2N...

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BUNIHPPS – An Online Research Survey for Narcolepsy & IH Patients

http://tiny.cc/BUNIHPPS Dear IH Community members: A research team at Boston University has developed BUNIHPPS -- a survey research study for patients with narcolepsy and idiopathic hypersomnia. Also called the Boston University Narcolepsy and Idiopathic Hypersomnia Patient Perspectives Study, BUNIHPPS is an anonymous online survey forging into new...

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A Comparison of Sodium Oxybate in the Treatment of Idiopathic Hypersomnia and Narcolepsy Type 1

Background Sodium oxybate (SXB) is a drug sold as Xyrem in the United States by Jazz Pharmaceuticals, in Europe by UCB Pharma, and in Canada by Valeant Pharmaceuticals. It is approved in the United States in adults for the treatment of excessive daytime sleepiness (EDS) and...

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Does Excessive Daytime Sleepiness Affect Children’s Pedestrian Safety?

Background Each year, approximately 30,000 children are unintentionally killed or injured while walking outside (typically within a half mile of their homes). Many factors—including children’s thinking and reasoning abilities, attention spans, reaction times, impulsiveness, and willingness to take risks—likely play a role. Excessive daytime sleepiness (EDS),...

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Raising Awareness of the Underpinnings of Hypersomnia

Awareness of disease means different things to different people. One’s awareness takes origin in experiences and goals, both personal and professional. Diversity in awareness therefore comprises our community of people who have hypersomnia, their significant others, healthcare professionals, and research scientists. People who have hypersomnia need...

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