A Web-based Observational Study of Patient-reported Outcomes in Adults With Narcolepsy
This is the Nexus Narcolepsy registry, a joint venture of Jazz Pharmaceuticals, Narcolepsy Network, and Wake Up Narcolepsy. See ClinicalTrials.gov. NOW RECRUITING people with narcolepsy internationally: CLICK HERE to register.
Stanford University’s Kleine-Levin Syndrome Study
The Nuvigil and Provigil Pregnancy Registry
Pitolisant Expanded Access for Patients with Narcolepsy
Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy
NOW RECRUITING in the USA: CLICK HERE. Jazz Pharmaceuticals also has a study arm for OSA (obstructive sleep apnea), which is also RECRUITING – CLICK HERE. And a separate 4-week study of safety, efficacy, and pharmacokinetics of JZP-110 in Parkinson’s disease with excessive daytime sleepiness, which is also currently RECRUITING – CLICK HERE. There are also several separate studies of JZP-110, which are ongoing but no longer recruiting: 1) 12-week safety and efficacy in OSA – CLICK HERE; 2) 12-week safety and efficacy in narcolepsy – CLICK HERE; 3) long-term safety in narcolepsy and OSA – CLICK HERE; and 4) 6-week study of safety and efficacy in OSA – CLICK HERE. See Past Research Studies tab for current results.
A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy
Jazz Pharmaceuticals’ trial completed: CLICK HERE. ADX-N05 is another name for JZP-110, as above.
XW Labs’ Phase 1 Study in Australia for Treatment of Narcolepsy with XW10172
Clock and Narcolepsy Genetic Variants and the Effects of Stalevo® (Levodopa/Carbidopa/Entacapone) on Sleep Disorders in Parkinson’s Disease
NOW RECRUITING in S. Korea: CLICK HERE. Medicine available for off-label treatment in the USA.
A Study to Evaluate the Safety and Efficacy of TS-091 in Patients With Narcolepsy
Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Patients with Narcolepsy
Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy
NOW RECRUITING in Ireland: CLICK HERE. Phase 3 clinical trial of single-dose sodium oxybate by Avadel Pharmaceuticals (formerly Flamel, prior to 2017 merger).
Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients
Theranexus THN102 (modafinil/flecanide combo). NOW RECRUITING in France: CLICK HERE. For more info: 1) First Clinical Study Completed on Effectiveness of Possible Narcolepsy Drug THN102. Flecainide is “an antiarrhythmic agent used in this instance at very low dosages and for its modulating effects on the glial connexins”; and 2) Hungary OKs Phase 2 Clinical Trial of Drug Candidate for Excessive Daytime Sleepiness in Parkinson’s.
Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder
NOW RECRUITING in France: CLICK HERE.
Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
NOW RECRUITING at Tangdu Hospital in Xi’an, Shaanxi Province, China: CLICK HERE.