oxybates« Back to Glossary Index
Oxybates are a class of medications used to treat hypersomnias, including narcolepsy and IH. They are central nervous system depressants, salts of gamma hydroxybutyrate (GHB), which is an endogenous compound and a metabolite of the neurotransmitter GABA. Currently U.S. FDA-approved forms include sodium oxybate (e.g., Xyrem) and low-sodium oxybate (e.g., Xywav). These are both taken at bedtime (and usually again during the night), promoting deep sleep and improving daytime sleepiness and cataplexy. Read more at MedlinePlus.gov about sodium oxybate and low-sodium oxybate. Also, see HF’s Treatment web page.