Hypersomnia Foundation

Histamine

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Histamine is a substance produced in the body that acts as a neurotransmitter. It is an important part of the reticular activating system (the part of the brain that wakes people up). Histamine may serve as a biomarker for problems or dysfunction in the hypothalamus. It is also involved in a number of activities, including the body’s immune and inflammatory responses and regulating the function of the gut.

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