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Ritanserin is a serotonin receptor antagonist which has been shown in humans to increase deep slow-wave sleep and to improve symptoms in a variety of psychiatric disorders, including OCD, acute mania, and schizophrenia. While it is not currently available in the U.S., it is available in Europe. In a 2003 study of 134 persons with narcolepsy, adding ritanserin to their usual narcolepsy treatment resulted in a significant increase in nocturnal slow-wave deep sleep and significantly reduced non-REM Stage 1 percentage during daytime sleep. Read more about ritanserin on HF’s Treatment web page HERE.

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