Scientific Advisory Board
David Rye, MD, PhD, Chair – Dr. Rye is Professor of Neurology at Emory University, Board Certified in Neurology and Sleep Medicine. He has received the American Academy of Neurology’s Sleep Science Award and the Sleep Research Society’s Outstanding Scientific Achievement Award for the discovery of the genetic contributions of restless legs syndrome. He has also received Narcolepsy Network’s Researcher of the Year Award which recognizes the Emory team’s more recent contribution to our understanding of the origins and treatments for hypersomnia. He and the Emory team are making new discoveries into the origins and treatments of hypersomnia that are transforming the way medicine is practiced.
Professor Nicholas Franks, FRSB, FRCA, FMedSci, FRS – As Professor of Biophysics & Anaesthetics at London’s Imperial College, Prof. Nicholas Franks has sought to understand how general anesthetic agents work at the molecular, cellular, and, most recently, neuronal network levels. Almost 40 years ago, he asked the question, “Where do general anaesthetics act?” in the journal Nature and has been pursuing the answer through funded studies in his laboratory since that time. Along the way, he has expanded his research to better understand the relationships among anesthesia, consciousness, and sleep and has also asked, and answered, the question, “Do sedatives engage natural sleep pathways?” Among the many discoveries that he has made throughout his long and storied career, Prof. Franks recently identified the exact binding location of propofol to the GABA-A receptor.
In 2007, Prof. Franks was elected Fellow of the Royal College of Anaesthetists and, in 2011, Fellow of the Royal Society. He has been awarded the Ebert Prize of the American Pharmaceutical Association, the Gold Medal of the Royal College of Anaesthetists, and the Excellence in Research Award from the American Society of Anesthesiologists.
James M. Krueger, PhD – Dr. Krueger is Regents Professor of Neuroscience in the Elson S. Floyd College of Medicine at Washington State University. Early in his career as a postdoctoral fellow, Dr. Krueger worked with Dr. John Pappenheimer to isolate, purify, and characterize Factor S and subsequently published their seminal work inThe Proceedings of the National Academy in 1978. Today he is recognized as a worldwide expert on sleep in his own right.
Among Dr. Krueger’s numerous awards are election to the Washington State Academy of Sciences and recipient of theDoctorem Medicinae Honoris Causa from the University of Szeged, the Distinguished Scientist Award from the Sleep Research Society, and the Senator Jacob Javits Award in the Neurosciences from the National Institutes of Health.
Dr. Krueger’s research has been continuously funded by the National Institutes of Health for over 28 years; it is focused on the biochemical regulation of sleep, molecular mechanisms responsible for the effects of infectious diseases and inflammation on sleep, sleep function, and brain organization of the initiation of sleep. Dr. Krueger’s 350 peer-reviewed publications cover the gamut from sleep function to sleep and cytokines, and physiological markers of localized sleep. His latest research documents his theoretical predictions that sleep originates in small neural networks, discoveries that open the door to a deeper appreciation of the genetic, molecular, and electrical aspects of sleep disorders.
Jeff Gulcher, MD, PhD is Chief Scientific Officer for WuXi NextCODE. Previously he was Chief Scientific Officer and co-founder of deCODE Genetics. Dr. Gulcher was on staff in the Department of Neurology at Beth Israel Hospital and Harvard Medical School from 1993 to 1998. He received his Ph.D. and M.D. from the University of Chicago in 1990, and completed his neurology residency Brigham and Women’s Hospital and Beth Israel Hospital of Harvard Medical School in 1996. He received a Bachelor Degree in Chemistry/Physics from Michigan State University in 1981. He has co-authored 198 peer-reviewed publications on the genetics of common/complex diseases.